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Preparation of Combined Inactivated Oil Adjuvanted Pasteurella Spp. and Clostridium Spp. Vaccine (Pneumoclost) in Sheep

Article

Last updated: 01 Jan 2025

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Tags

Veterinary Parasitology & Microbiology

Abstract

This study, aimed to prepare and evaluate a combined Pasteurella Spp. and Clostridium Spp. vaccine in two groups of one-year-old sheep. The first group was immunized with that vaccine and the second was kept as a negative control. All first group individuals were injected with two doses (1 month apart). This group showed the highest antibody titres after the second dose in the fourth month for M. hemolytica type A and P. multocida type A and the fifth for P. multocida (B6 and D) and P. trehalosi, when it was evaluated by IHA test. A passive mouse protection test was used for P. multocida (A, B6 and D) protection rate evaluation and revealed that 96% protection for A and B6 but 93% for D. SNT was used for Clostridium Spp. evaluation. The first month was the highest titers for C. tetani, C. perfringens, and by agglutination titer for C. chauvoei. The fourth month was the highest titer for C. septicum. The fifth month was the highest titer for C. novyi (B). ELISA test results revealed that the first month was the highest titers for C. chauvoei, C. tetani, and C. perfringens. The fourth month was the highest titer for C. septicum. The fifth month was the highest titer for C. novyi (B). The second group had no significant changes all over the experiment duration. Briefly, this vaccine has protective effects, achieving protection for sheep against illness and elevating the multi-handling and injection stress on the livestock and the workers efforts.

DOI

10.21608/ejvs.2024.267090.1820

Keywords

Pasteurella, Mannheimia, clostridia, polyvalent, vaccine

Authors

First Name

Fatma

Last Name

Ibrahim

MiddleName

-

Affiliation

Aerobic Bacteria Research Department, Veterinary Serum and Vaccine Research Institute (VSVRI), Abbasia, Agricultural Research Center (ARC), 131, Cairo, Egypt

Email

dr.fatma_vet@yahoo.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

Ismail

MiddleName

Tawfik Ahmed

Affiliation

Aerobic Bacteria Research Department, Veterinary Serum and Vaccine Research Institute (VSVRI), Abbasia, Agricultural Research Center (ARC), 131, Cairo, Egypt

Email

drmody_vet@yahoo.com

City

-

Orcid

0000-0002-2729-784X

First Name

Manal

Last Name

Mohamed

MiddleName

-

Affiliation

Aerobic Bacteria Research Department, Veterinary Serum and Vaccine Research Institute (VSVRI), Abbasia, Agricultural Research Center (ARC), 131, Cairo, Egypt

Email

manalfawzy201@gmail.com

City

-

Orcid

-

First Name

Marwa

Last Name

Ahmed

MiddleName

-

Affiliation

Anaerobic bacteria department, Veterinary Serum and Vaccine Research Institute (VSVRI), Abbasia, Agricultural Research Center (ARC), 131, Cairo, Egypt

Email

zidanmarwa@gmail.com

City

-

Orcid

-

First Name

Moustafa

Last Name

Zaghloul

MiddleName

-

Affiliation

Central Laboratory for Evaluation of Veterinary Biologics (CLEVB), Agricultural Research Center (ARC), 131, Cairo, Egypt

Email

moustafazaghlool@gmail.com

City

-

Orcid

-

First Name

Yasser

Last Name

Adawy

MiddleName

-

Affiliation

Anaerobic bacteria department, Veterinary Serum and Vaccine Research Institute (VSVRI), Abbasia, Agricultural Research Center (ARC), 131, Cairo, Egypt

Email

yasseradawy@gmail.com

City

-

Orcid

-

First Name

Eman

Last Name

El Rawy

MiddleName

-

Affiliation

Aerobic Bacteria Research Department, Veterinary Serum and Vaccine Research Institute (VSVRI), Abbasia, Agricultural Research Center (ARC), 131, Cairo, Egypt

Email

emanelrawy40@gmail.com

City

-

Orcid

-

Volume

56

Article Issue

5

Related Issue

48063

Issue Date

2025-05-01

Receive Date

2024-02-17

Publish Date

2025-05-01

Page Start

875

Page End

884

Print ISSN

1110-0222

Online ISSN

2357-089X

Article File

EJVS_Volume 56_Issue 5_Pages 875-884.pdf

PDF . 878.9kB

Link

https://ejvs.journals.ekb.eg/article_357671.html

Detail API

https://ejvs.journals.ekb.eg/service?article_code=357671

Order

357,671

Type

Original Article

Type Code

140

Publication Type

Journal

Publication Title

Egyptian Journal of Veterinary Sciences

Publication Link

https://ejvs.journals.ekb.eg/

MainTitle

Preparation of Combined Inactivated Oil Adjuvanted Pasteurella Spp. and Clostridium Spp. Vaccine (Pneumoclost) in Sheep

Details

Type

Article

Created At

23 Dec 2024