Investigating clinical and histopathological effects of the topical application of Hypericum and omental extracts on healing in skin wound of the rabbits. Fifteen rabbits were divided into 3groups (4, 7, and 14-day intervals). In each animal, three circular excisions about 2cm were created, Control defect (CD), Hypericum defect (HD), and Omental defect (OD). Defects were observed clinically for rates of contraction. Biopsies were taken for histopathological examinations; sections were stained with H&E and Mason's trichrome stains. Clinical comparison at 4 days interval showed no significant differences among three groups. At 7 days interval showed significant decrease in size of HD comparing to CD at p-value (0.0132), while there were no significant differences between HD and OD between neither CD nor OD.  At 14 days interval, the difference between HD and CD was highly significant (pvalue 0.0024), between HD and OD was significant (pvalue 0.0290), while between OD and CD was not significant (p value 0.3717). Histopathological examinations showed increased, number of fibroblasts and collagen, and angiogenesis rate, at 7-day interval and more re-epithelialization at 14-day interval in HD and OD comparing to the CD. It was concluded from results that there were positive effects of Hypericum and Omental extracts on healing process through increasing.