Diphenol-A (bisphenole-A) can leach into meals and beverages from containers containing Diphenol A. Diphenol A exposure is concerning due to the potential consequences on the brain and organs of fetuses, babies, and children. To be assess the teratological and histopathological changes in the eyes of chick embryos that exposure to Diphenol we used number of 150 fertilized chicken eggs divided into 6 groups (Diphenol given in the second day of incubation, injected in to the air sac). G1, Negative control group chicks embryos without any exposure. G2, Positive control treated with corn oil. G3,  treated with 0.0125 μL /egg Diphenol. G4, 0.025 μL /egg Diphenol. G5, 0.05 μL /egg Diphenol. G6, 0.1 μL /egg Diphenol. The chick embryos was euthanized at a developmental stage of (21) day.  The study examined eye tissues for histopathological changes, revealing a range of abnormalities in different groups  in subsequent treatment groups (G3 to G6), pathological alterations were identified. Groups G3 to G6 showed blood vessels, hemorrhagic foci, moderate degeneration in nerve fiber layers, edema in the nuclear fiber layer, and severe degenerative changes in the lamina pectoris, fibrous layer cells, and rods and cones layer of the retina. The study concluded that Diphenol  may have teratological and histological abnormalities in the eyes of chicken embryos  and  that warrant further investigation.