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Early Detection of Renal Damage Using Kidney Injury Molecule -1 (KIM-1) In Dogs Associated with Dehydration

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Veterinary Pathology & Animal Diseases

Abstract

Background: Dehydration may be associated with a declined kidney function and serious signs of kidney injury. The kidney response differently to dehydration levels which are not yet known. Aim: detection of the effect of dehydration on kidney functions levels and kidney injury biomarkers in dehydrated dogs and compare it to normal. Material and methods: A total number of 12 dogs were enrolled in this study (6 dehydrated and 6 controls). Inclusion criteria was presence of history of fluid loss for 48-hour, dehydration stage based on clinical assessment and the assessment of urine specific gravity. Blood samples were withdrawn from each animal on Ethylenediamine tetraacetic acid tube for hematology and plain tube to estimate total protein, albumin, BUN and creatinine. Ultrasonography was conducted on non-sedated dogs using a micro convex 5–8 MHz transducer. Urine samples were acquired through catheterization to determine urine specific gravity, then urine sediment was derived by centrifugation and commercially available Enzyme-linked immunoassay test was utilized to assess the levels of kidney injury molecule-1. Results: Hematological parameters showed non-significant elevation in packed cell volume in association with significant elevation in mean corpuscular volume were recorded in dehydrated dogs. Non-significant elevation in blood urea nitrogen, creatinine, and total protein were recorded in dehydrated dogs compared with control dogs. Urinalysis showed significant elevation in urine specific gravity and KIM-1 (P value ≤0.05) in urine samples of dehydrated dogs compared to control dogs. Conclusion, dehydration state might be impact the reading of urinary KIM-1 even in the absence of apparent azotemia.

DOI

10.21608/ejvs.2024.272623.1880

Keywords

Dehydration, Kim-1, dogs, Kidney Injury

Authors

First Name

Noha

Last Name

Ryad

MiddleName

Mahmoud

Affiliation

Department of internal medicine and infectious diseases, faculty of veterinary medicine, cairo university

Email

noha.reyad94@gmail.com

City

-

Orcid

0009-0006-6328-0830

First Name

Eman

Last Name

Ramadan

MiddleName

Shawky

Affiliation

Department of internal medicine and infectious diseases, faculty of veterinary medicine, cairo university

Email

emanshawky10@yahoo.com

City

cairo

Orcid

-

First Name

Mohamed

Last Name

El khiat

MiddleName

Awny

Affiliation

Department of internal medicine and infectious diseases, faculty of veterinary medicine, cairo university

Email

bebo_awny56@yahoo.com

City

cairo

Orcid

-

First Name

noha

Last Name

salem

MiddleName

Yousef

Affiliation

Department of internal medicine, Faculty of Veterinary Medicine, Cairo University

Email

nemovet2011@gmail.com

City

Giza

Orcid

0000-0002-3376-8695

First Name

Ibrahim

Last Name

Saleh

MiddleName

Abdelsatar

Affiliation

Department of internal medicine and infectious diseases, faculty of veterinary medicine, cairo university

Email

saleh.ibrahim12@yahoo.com

City

cairo

Orcid

-

Volume

56

Article Issue

2

Related Issue

47435

Issue Date

2025-02-01

Receive Date

2024-02-28

Publish Date

2025-02-01

Page Start

369

Page End

375

Print ISSN

1110-0222

Online ISSN

2357-089X

Link

https://ejvs.journals.ekb.eg/article_352990.html

Detail API

https://ejvs.journals.ekb.eg/service?article_code=352990

Order

352,990

Type

Review Artical

Type Code

329

Publication Type

Journal

Publication Title

Egyptian Journal of Veterinary Sciences

Publication Link

https://ejvs.journals.ekb.eg/

MainTitle

Early Detection of Renal Damage Using Kidney Injury Molecule -1 (KIM-1) In Dogs Associated with Dehydration

Details

Type

Article

Created At

23 Dec 2024