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347414

Expression of Vitamin D Receptor Gene (VDR) and Associated Cytokine Response in Arabian Horses with Chronic Inflammatory Airway Disease

Article

Last updated: 01 Jan 2025

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Tags

Veterinary Pathology & Animal Diseases

Abstract

Inflammatory airway disease (IAD) represents inflammatory conditions of the lower respiratory tract. IAD occurs in athletic horses and is a common cause of training interruption and impaired performance. The aim of this investigation was to evaluate the relationship between the Vitamin D Receptor (VDR) gene and cytokines in horses with chronic IAD. Ten horses with IAD and five clinically healthy horses were studied. Serum levels of tumor necrosis alpha (TNF-α) and interleukin-1β (IL-1β) were measured, and real-time PCR was used for relative quantification of the mRNA level of the VDR gene in horse blood samples. Clinically, horses under investigation suffered from IAD showing mucopurulent nasal discharge, increased respiratory rate, chronic cough, and abnormal lung and tracheal sounds. A significant increase in IL-1β (p < 0.01) and TNF (p < 0.01) levels was recorded in horses with chronic IAD compared to those in clinically healthy horses. However, VDR gene expression was significantly decreased (p < 0.001) in horses with chronic inflammatory airway disease compared to that in the controls. There was a positive correlation between IL-1β and TNF-α levels (r =, p = 0.001). However, a negative correlation was observed between VDR gene expression and   IL-1β and TNF-α levels. In conclusion, the results of the present study indicate that VDR gene has a major role in the occurrence of IAD in horses. Further studies on the role of vitamin D as a preventive therapy for IAD are required in clinical practice.

DOI

10.21608/ejvs.2024.268973.1840

Keywords

Respiratory diseases, equine, IL-1β, TNF-α, Vitamin D

Authors

First Name

Heyam

Last Name

Haddadi

MiddleName

-

Affiliation

Department of Clinical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia

Email

220034563@student.kfu.edu.sa

City

-

Orcid

-

First Name

Mohamed

Last Name

Marzok

MiddleName

-

Affiliation

Department of Clinical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia

Email

mmarzok1968@gmail.com

City

-

Orcid

-

First Name

Heba

Last Name

Moharam

MiddleName

-

Affiliation

Veterinary Teaching Hospital, faculty of Veterianry Medicine, Mansoura University, Mansoura 35516, Egypt

Email

hebamoharam@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Rizk

MiddleName

-

Affiliation

Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt

Email

mrizk1223@yahoo.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

Kandeel

MiddleName

-

Affiliation

Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia,

Email

mkandeel@kfu.edu.sa

City

-

Orcid

-

First Name

Adel

Last Name

Almubarak

MiddleName

-

Affiliation

Department of Clinical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia

Email

aalmubarak@kfu.edu.sa

City

-

Orcid

-

First Name

Saad

Last Name

Shousha

MiddleName

-

Affiliation

Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia,

Email

sshousha@kfu.edu.sa

City

-

Orcid

-

First Name

Hussam

Last Name

Ibrahim

MiddleName

-

Affiliation

Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt

Email

dr_hussamhabosha@yahoo.com

City

-

Orcid

-

First Name

sabry

Last Name

El-khodery

MiddleName

-

Affiliation

Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt

Email

khodery@mans.edu.eg

City

-

Orcid

-

Volume

56

Article Issue

1

Related Issue

46825

Issue Date

2025-01-01

Receive Date

2024-02-11

Publish Date

2025-01-01

Page Start

11

Page End

20

Print ISSN

1110-0222

Online ISSN

2357-089X

Article File

EJVS_Volume 56_Issue 1_Pages 11-20.pdf

PDF . 1.1MB

Link

https://ejvs.journals.ekb.eg/article_347414.html

Detail API

https://ejvs.journals.ekb.eg/service?article_code=347414

Order

347,414

Type

Original Article

Type Code

140

Publication Type

Journal

Publication Title

Egyptian Journal of Veterinary Sciences

Publication Link

https://ejvs.journals.ekb.eg/

MainTitle

Expression of Vitamin D Receptor Gene (VDR) and Associated Cytokine Response in Arabian Horses with Chronic Inflammatory Airway Disease

Details

Type

Article

Created At

23 Dec 2024