Medicinal plants (MP) have been demonstrated to be a plentiful spring of biological vigorous compounds for the improvement of novel indication compounds for drugs. Screening of Artemisia judaica (A.judaica) and Lavandula dentate (L.dentate), plant extracts approve the occurrence of several phytochemicals alike carbohydrates, cardiac glycosides, coumarins, flavonoids, tannins, terpenoid, steroids and phenols in the selected plants. While other phytochemicals such as anthraquinone, alkaloids, saponins, proteins, and phytosterols were detected and varied based on the plant constituents. The antioxidant, antibacterial and antifungal actions of the plant extract were recognized. The antioxidant activity was assessed by DPPH. The antimicrobial action was bioassayed by the agar well diffusion technique. The results approved the character of these extracts as talented, strong antioxidants and moderate antimicrobial representatives. The impartial of this work was to conclude the phytochemical broadcast, investigation by LC-MS/MS, the antioxidant, antimicrobial activities of A. judaica and L.denta, ethanolic extract acquired from AlBaha in the Kingdom of Saudi Arabia.