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344159

Comparison of the Analgesic, Antipyretic, and Anti-inflammatory Efficiency Between Nimesulide and Aspirin in Mice

Article

Last updated: 23 Dec 2024

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Tags

Pharmacology & Toxicology

Abstract

The NSAIDs are drugs that differ in their pharmacological efficacy depending on their selectivity against COX2 enzyme. Therefore, the aim of study was to compare the pharmacological effects (analgesic, antipyretic, and anti-inflammatory) between nimesulide (selective) and aspirin (nonselective) COX2 inhibitors in mice. Analgesic ED50s for nimesulide and aspirin were 7.9 and 212.23 mg/kg, respectively. Both drugs exert their effects in a dose-dependent routine. The visceral analgesia (writhing reflex induced by 1% acetic acid) of nimesulide (15.8 mg/kg, i.m.) and aspirin was examined and revealed a significant superiority of nimesulide over aspirin (424.5 mg/kg, i.m) in decreasing the numbers of writhing reflex and percentages of inhibition in writhing numbers to be 66 and 46 %, respectively. The antipyretic effect of nimesulide was significantly more efficient than aspirin through decreasing the fever which induced by baker's yeast (135 mg/kg, i.p.) for overall measured times after injection at 1, 2, 3, and 4h while aspirin has a good and significant antipyretic action after 2h of baker's yeast injection. Formalin (1%) induced inflammation when injected in the paw for the positive (control) group of mice in comparison to the negative (control) group (injected with saline solution) while nimesulide decreased the inflammation in a good manner unlike the aspirin at 0.5, 1, and 2h after formalin injection. Our data demonstrate that nimesulide has better pharmacological properties than aspirin which is related to analgesia, anti-pyresis, and anti-inflammatory effect in mice which makes it useful for practical use in the field of veterinary medicine.

DOI

10.21608/ejvs.2024.253221.1698

Keywords

Analgesia, antipyretic, Anti-inflammatory, Nimesulide, aspirin, Mice

Authors

First Name

Taimaa

Last Name

Yahya

MiddleName

Adlan

Affiliation

Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq

Email

taimaaadlan1980@gmail.com

City

Mosuم

Orcid

0009-0009-8361-2611

First Name

Yaareb

Last Name

Mousa

MiddleName

Jaafar

Affiliation

Department of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul-Iraq

Email

yarub204@uomosul.edu.iq

City

Mosul

Orcid

0000-0003-0004-097X

Volume

55

Article Issue

6

Related Issue

45998

Issue Date

2024-11-01

Receive Date

2023-12-04

Publish Date

2024-11-01

Page Start

1,697

Page End

1,703

Print ISSN

1110-0222

Online ISSN

2357-089X

Article File

EJVS_Volume 55_Issue 6_Pages 1697-1703.pdf

PDF . 583.1kB

Link

https://ejvs.journals.ekb.eg/article_344159.html

Detail API

https://ejvs.journals.ekb.eg/service?article_code=344159

Order

344,159

Type

Original Article

Type Code

140

Publication Type

Journal

Publication Title

Egyptian Journal of Veterinary Sciences

Publication Link

https://ejvs.journals.ekb.eg/

MainTitle

Comparison of the Analgesic, Antipyretic, and Anti-inflammatory Efficiency Between Nimesulide and Aspirin in Mice

Details

Type

Article

Created At

23 Dec 2024