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343283

Resveratrol inhibits Cell Cycle Dynamics, Caspase Activation, and Programmed Cell Death: Implications for Cancer Treatment in MCF-7 Cells"

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Pharmacology & Toxicology

Abstract

Resveratrol is a plant-derived polyphenol known for its anti-inflammatory and anti-tumor properties in laboratory models and living organisms. Recent studies suggest that certain analogs of resveratrol may exhibit more effective anti-tumor factors. This study investigates the impact of resveratrol on the cell cycle of MCF-7 cells at concentrations of 1.5 and 2µg\ ml. Resveratrol, at 2µg\ml, significantly alters the cell cycle distribution, indicating a concentration-dependent effect. Doxorubicin serves as a positive control and induces G1 phase arrest. These results contribute to understanding the potential mechanisms of resveratrol in cancer treatment and shed light on its impact on cell cycle dynamics. Additionally, the study explores the effects of different concentrations of resveratrol on the activity of Caspase 8, using doxorubicin as a positive control for comparison. Human cell lines were exposed to varying concentrations of resveratrol (1.5 µg\ ml and 2 micrograms/ml), and Caspase 8 activities were compared with both untreated cells (control group) and those treated with doxorubicin. The average Caspase 8 activity and standard deviation were calculated for each treatment group, and the statistical significance was determined. this study highlights the concentration-dependent effects of resveratrol on the cell cycle distribution of MCF-7 cells, suggesting its potential as a therapeutic agent in cancer treatment. Furthermore, the investigation of Caspase 8 activity provides additional insight into the anti-cancer properties of resveratrol in breast cells.

DOI

10.21608/ejvs.2024.263893.1787

Keywords

Resveratrol, Cell cycle dynamics, Caspase activation, MCF-7 cells, Doxorubicin, apoptosis, Mitochondrial membrane

Authors

First Name

Sura

Last Name

Hamad

MiddleName

H.

Affiliation

Al Maaref University College. Iraq

Email

surahamad@gmail.com

City

-

Orcid

-

First Name

zinah

Last Name

Musleh

MiddleName

Hashim

Affiliation

Ministry of Education, General Directorate of Education, Anbar

Email

zinahhm@gmail.com

City

-

Orcid

-

First Name

Kawther

Last Name

Nasir

MiddleName

M.

Affiliation

College of Education for women, University of Anbar, Iraq

Email

kawthermn@gmail.com

City

-

Orcid

-

First Name

Ashwaq

Last Name

Hameed

MiddleName

T

Affiliation

University of Anbar, College of Education for women

Email

ashwaq.talib@uoanbar.edu.iq

City

-

Orcid

-

First Name

Georgette

Last Name

Eskander

MiddleName

-

Affiliation

Faculty of Pharmacy, Ain Shams University, Postgraduate Student, Cairo, Egypt

Email

georgettee@gmail.com

City

-

Orcid

-

Volume

55

Article Issue

6

Related Issue

45998

Issue Date

2024-11-01

Receive Date

2024-01-18

Publish Date

2024-11-01

Page Start

1,659

Page End

1,668

Print ISSN

1110-0222

Online ISSN

2357-089X

Link

https://ejvs.journals.ekb.eg/article_343283.html

Detail API

https://ejvs.journals.ekb.eg/service?article_code=343283

Order

343,283

Type

Original Article

Type Code

140

Publication Type

Journal

Publication Title

Egyptian Journal of Veterinary Sciences

Publication Link

https://ejvs.journals.ekb.eg/

MainTitle

Resveratrol inhibits Cell Cycle Dynamics, Caspase Activation, and Programmed Cell Death: Implications for Cancer Treatment in MCF-7 Cells"

Details

Type

Article

Created At

23 Dec 2024