Dystocia in a feline (queen) refers to the inability of the fetus to explode or for the kitten to be delivered through the birth canal during the six to twelve hour labor period. Partial or complete non-dilatation of the cervix is more cause of dystocia. The study was conducted at the Veterinary Teaching Hospital affiliated with the College of Veterinary Medicine, University of Mosul, and the veterinary centers for small animals in the city of Mosul. Thirty cats suffering from dystocia due to non-dilatation of the cervix were selected. The study animals were divided into three groups randomly, with each group including 10 animals. The first group was given the hormone oxytocin at a dose of 5 IU with dexamethasone 2 mg, while the second group was given the hormone prostaglandin F2α at a dose of 25 mcg with dexamethasone 2 mg and the third group was given the hormone estradiol cypionate at a dose of 1 mg with dexamethasone 2 mg for each animal. The study parameters are: response rate, response onset time, time of birth, whether there were problems that appeared in the mother after birth, and uterine involution.  The study's findings revealed that response rate to treatment in G1,G2 and G3 were 80%,70% and 60%, respectively, with a significant difference (P= <1.000). We conclude that oxytocin with dexamethasone is best protocol for treatment of  dystocia ( cervix indilatation).