This investigation was done to know the infection rate of Otodectes cynotis in cats in Fallujah city and to know the best treatment for these cases. The Survey was conducted on domestic 140 cats with different ages, which were randomly presented in veterinary clinics for reasons unrelated to parasitic disease from a period from June 2022 to June 2023 in Fallujah city/Iraq. At their initial inspection at a private small animal clinic, the ear canals of all cats were examined using an otoscope to check for the presence of Otodectes. The ears of every cat that tested positive were cleaned many times with warm paraffin oil. To do this, by injected paraffin oil into the ear canal using a 5 cm3 syringe and collected the resulting debris in a Petri plate. To quantify the level of parasitism, we examined this wash using a microscope. This study included treatment for these cases by 2 components as follows: G1 included 25 animals who were treated with one drop of ivermectin single dose and G2 included 25 animals who were treated with one drop of Mixture of bioline company single dose. The current study showed that from 140 animals, the infection rate by Otodectes cynotis was 51 (36.4%), while the age group 1-6 months was more highly infected than other groups. The current study exhibited that ivermectin with a single dose gives a significant result when compared with another treatment in G2.