Tetrachlorodibenzo-p-dioxin (TCDD), (TCDD), dioxin 2, 3, 7, 8, and other 75 tricyclic aromatic chemicals that pose serious risks and are structurally linked, one of these compounds is persistent in the environment, accumulates in the food chain, and acts toxically in a similar way. The research aimed to examine the toxic pathological consequences of TCDD in albino female rats' reproductive system for the purpose of the current study. The experiment utilized an interventional design and divided the sixty female rats into randomly and equally two groups. The first group was the control group, while the second group received the medication orally for 120 days, at 0.1 mg / Kg.  b.w of TCDD. All animals were sacrificed under slight ether anesthesia for blood collection for biochemical assay, especially for sex hormones and reproductive system. The ovary and uterus were immediately removed and examined to record any abnormal size, color adhesion and consistency. The results elucidated that the biochemical assay revealed all sex hormones significantly decreased p≤0.05. The reproductive organs of the second group showed severe damage characterized by ovary hyper-cellularity of the granulose layer and increased follicular development in the cortex layer. Uterus characterized by endometrial gland cystic dilation, necrosis, abscess in endometrial and myometrium, lymphocytic granuloma with extensive hemorrhage in endometrial and myometrium. These findings suggest that the administration of TCDD induced pronounced hazardous effects in the female reproductive system, sex hormones and pathological effects in genitalia.