The time period for healing bone fractures in humans and animals is extremely important. This study aimed to compare the effect of tricalcium phosphate putty and granules on bone defect healing in sheep. The study included 4 male sheep. Each animal underwent tibia surgery by creating three defects in the same tibia, the first to apply the granule material, the second to control, and the third to apply the putty material, with an observation period of 2-8 weeks. Significant differences were observed in the number of osteocytes between the granule groups and the putty group compared to the control in the different period. Both forms showed an increase in the number of osteocytes. A significant decrease was recorded in the number of osteoblast cells in the putty group after 8 weeks of treatment. It was found that the speed of resorption of the putty material was faster in the putty form than in the granules, and the speed of the bone's response to healing was faster during the same period. The granule group displayed consistently moderate Ki67 expression at 2, 4, 6, and 8 weeks, and conversely, the putty group showed intense Ki67 expression at 4 weeks and 8 weeks. Both forms showed a good response to the healing of the bone defect, although. The putty form of β-TCP was better, had faster resorption after 8 weeks of treatment compared to the granular form.