Obesity represent a real challenge to the human beings and affects greatly the reproductive capacities, metabolic disorders and cardiovascular diseases. Obesity is related greatly with series of oxidative damage and excessive production of free radicals with incidence of inflammation which is considered to be one of the essential factors that affect the reproductive world health. The current study evaluated the effects of obesity (OBS) on the reproductive capacity functions via hormonal measurements (Testosterone hormone level), inflammatory markers [C-reactive protein (CRP) and interleukin-6 (IL-6)] and (CAT , SOD and GPx) which are the vital antioxidant enzymes and final lipid peroxidation marker (MDA) in testis homogenates plus histological structure and caspase-3 staining sections of the testicular tissues. 50 Male rats were used in the present study and they were divided into 5 treated groups: Control group, Experimentally induced obesity group (OBS) , OBS plus Orlistat (ORS) , OBS plus Metformin (MEF) and the last group OBS plus ORS plus MEF. Experimental induced obesity induced significant increment in testicular lipid peroxidation level, both inflammatory markers (CRP and Il-6) , tumor necrosis factor-α and lipid peroxidation marker in concurrent with decline in antioxidant enzymes (SOD, CAT and GPx) levels and damage of testicular main structures with degeneration of spermatogenic layers and detachment of seminiferous tubules with appearance of Azospermia, Meanwhile, restoration of normal testicular structures, and antioxidant levels in both groups treated with either ORS or MEF and the combination group was attained with the best results than each treatment alone .The current study proved the synergistic effect of both ORS and MEF on amelioration of testicular functions, hormonal levels and antioxidant enzyme levels and alleviation of inflammation , tumor necrosis marker and side effects of experimentally induced obesity.