The commercial herbicide, bispyribac-sodium, is widely utilized in agricultural to control weeds in rice fields. Although, it's efficacy in controlling unwanted plant growth is well established, there are concerns about its potential effects on non-target organisms, such as the fish. Clarias gariepinus is a commonly farmed species of catfish and its health is of economic importance to aquaculture operations. The aim of the present work is to investigate the effects of bispyribac-sodium on the liver functions and it's histopathology in C. gariepinus. The study was conducted over a period of 14 and 28 days, with fish being exposed to varying concentrations of bispyribac-sodium (High and low concentrations). At the end of exposure period, blood and liver samples were collected for analysis the liver functions and its histopathology. Results showed that, exposure to bispyribac-sodium caused significant changes in the liver functions as indicated by altered levels of liver enzymes, including aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), alkaline phosphatase (ALP), albumin and total proteins. Histopathological examination of the liver tissue declared that exposure to bispyribac-sodium caused hepatic damage including centrilobular vacuolization, degeneration of the hepatocytes and infiltration of immune cells. Results suggested that, exposure to bispyribac-sodium can cause significant harm to the liver of C. gariepinus and raises concerns about its potential effects on the health of other aquatic organisms. Therefore, future studies must be conducted to fully understand the mechanisms underlying these effects and to assess the potential risks posed by bispyribac-sodium to the aquatic environment.