Green Chemistry (GC) is designing chemical processes and products to decrease the use of harmful materials, based on 12 theories established in 1998. The pharmaceutical industry faces a significant problem due to the worldwide requirement to comply with Green Analytical Chemistry (GAC) requirements. High-pressure liquid chromatography (HPLC) is a widely used process in the medicine industry, but it produces massive quantities of organic hazardous waste. Analytical techniques must be optimized for precision, sensitivity, repeatability, effortlessness, cost effectiveness, versatility, and speed. Though, other factors such as analysts' security and ecological effects are rarely considered. Although there are more publications about green chromatography techniques, there has not been much adoption of eco-friendly HPLC techniques in the pharmaceutical business. The major causes of this are the need for adapting the standard HPLC apparatus, a lack of time, knowledge, or analysts' confusion over the fulfilment of the method requirements. An overview of green approaches for liquid chromatography (LC) that may be quickly applied to traditional instruments was provided to create eco-friendly HPLC procedures for pharmaceutical analysis.