The study aims to determine the therapeutic role of vitamin D3, k2, garlic extract, spirulina and calcium on induced hyperlipidemia. The experiment included 90 male white albino rats and was divided into two groups, the first group included 35 rats that were given a standard diet for two months, the second group included 55 rats that were fed on fodder with 4% cholesterol added for two months. After the end of the treatment period,the lipid profile was examined, and then the animals of the first group were divided into 7 groups and the second group into 11 groups. The groups were treated for a month with statin, vitamin D3, k2, garlic extract, spirulina and calcium the result showed increase in the level of cholesterol and triglyceride and decrease HDL in the hyperlipidemia group compared with the control group and decrease in the level of cholesterol and triglyceride in groups treated with statin, vitamin D3, k2 , garlic extract, calcium and spirulina compared with the hyperlipidemic group with increase in the level of HDL in groups were treated with statin, vitamin D3,vitamin k2, garlic extract, calcium and spirulina compared with hyperlipidemia group