Thirty calves of one-year old and body weight (BW. = ±152.5 kg) had been confirmed for presence of mixed infection of different internal parasites like Fasciola gigantica., Paramphistomum microbothrium., and (Trichostrongylidae spp.). These calves were used to evaluate the anthelmintic efficacy, growth performance, haemato-biochemical and serum antioxidant parameters of single oral administration of levanide® (levamisole (LEV)-oxyclozanide (OXY) combination as active principles) in a dose of 2.5 ml of the product /10 kg BW. The fecal egg count reduction test (FECRT) for the tested animals showed a significant (P<0.05) reduction in eggs per gram of feces for the examined parasites on 3rd day then on the 7th day post-treatment in comparison with pretreatment samples with a 100% anthelmintic efficacy. The growth parameters, and red blood corpuscle count (RBCs) were significantly (P<0.05) improved post-treatment compared to pretreatment measures. A slight reversible elevation of serum aspartate aminotransferase (AST) level was noticed on the third day to the 7th day after administration followed by a decrease in its activity till the end of the experiment. The total antioxidant capacity (TAC) was decreased from day 7 to the end of the trial; glutathione-S-transferase (GST) showed a slight decrease in activity after drugs administration followed by a marked rise (p < 0.05) in its activity on days 14 and 28. Accordingly, it could be concluded that administration of the LEV-OXY active principals combination is a successive, efficient and safe anthelmintic with minimal side effects that could help in increasing growth performance.