Introduction: In the textile dyeing industry; workers are exposed to chemical, physical, and mechanical hazards that can affect their health. Aim of Work : To assess health status, changes in selected blood parameters of occupationally exposed workers in textile dyeing industry, and to evaluate the implementation of safety measures at the workplace. Materials and Methods: A comparative cross-sectional study was carried out in textile dyeing units in Miser Spinning and Weaving Company at El Mahala El Kobra, Gharbyia Governorate, Egypt. The study included 100 exposed and 100 nonexposed
workers as a comparison group from the administrative sector. All workers were subjected to an interview-administrated questionnaire which included sociodemographic, occupational characteristics and some reported health complaints. Their liver enzymes, kidney functions, and complete blood counts were also measured. Results: All studied workers were occupationally exposed to chemicals, vapors, gases, and noise, while 58% were exposed to dust, and 68% to humidity and heat. Exposed workers suffered from runny nose (22%), watery eye (36%), and difficulty hearing (30%) . Liver enzymes (AST, ALT, and GGT) were high in 11% of the exposed group. Regarding CBC; neutropenia with relative lymphocytosis was the most frequent CBC finding among the exposed group (8%) of cases. No statistically significant differences were found between the two studied groups regarding CBC findings and renal function tests including urea and creatinine. Assessment of workplace environment by inspection checklist detected that only 38.5% of physical hazard items, 50% of chemical hazard items, and 57%of of fire hazards safety measure items were fulfilled at the workplace. Conclusion and Recommendations: The textile dyeing industry has adverse health effects on the exposed workers. So, applying the standard safety measures, regular environmental monitoring, and periodic examinations for workers are mandatory.