Introduction: Oral Mucositis is a multi-etiological inflammatory condition affecting patient's quality of life.
Objectives: The current study aims to evaluate the effect of both Platelet rich plasma (PRP) and Propolis on chemically induced labial mucosal ulcer in albino rats.
Material and Methods: 35 adult male albino rats weighing around 200-250 grams were subjected to chemical ulcer induction. Rats were divided into 4 main groups. Group I (negative control): rats did not receive any treatment. Group II in which ulceration was induced in the labial mucosa and left untreated to heal spontaneously. Group III (PRP): in which ulceration was treated by PRP. Group IV (Propolis): in which ulceration was treated by propolis. Each group was further subdivided into 2 equal subgroups A and B in which rats were sacrificed at 5&10 days following ulcer induction respectively. Labial mucosa were dissected and examined histologically and immunohistochemically.
Results: Histologically, group I showed normal findings of keratinized stratified squamous epithelium. Group II showed complete epithelial degeneration at day 5, re-epithelialization at day 10. Group III showed beginning of re-epithelization at day 5 and continuous epithelial lining at day 10. Group IV showed apparently moderate thickness of epithelium at day 5 and complete regeneration at day 10. Immunohistochemically and statistically, group IV showed highest immunopositive PCNA expression of epithelial cells followed by group III then group I then group II showed the lowest mean.
Conclusions: PRP and Propolis showed vast accelerating effects in healing of chemically-induced ulcers through increased vascularity and enhancing re-epithelization due to their anti-inflammatory and anti-oxidant potentials. Propolis proved to have superior effects compared to PRP