Introduction: Gastric ulcers greatly affect the quality of a patient's life and they may lead to major complications such as perforation, bleeding, and even death. Treatment is mainly medical. However, the medications are not effective in the treatment of all cases and may cause many adverse effects.
Aim of the Work: This work aimed to assess the protective effects of autologous platelet-rich plasma versus glutamine against aspirin-induced acute gastric ulcers in adult male albino rats.
Material and Methods: Fifty male albino rats were used, aged 6-8 months, weighing 180-200 grams each, randomly divided into six groups. Group I (Control group): subdivided into two subgroups: subgroup Ia: rats were kept without any treatment and subgroup Ib: each rat received a single oral dose of carboxymethylcellulose. Group II: each rat received 0.5ml/Kg prp subcutaneously two days/week for three weeks. Group III: each rat received 500 mg/kg/day of glutamine orally for three weeks. Group IV (gastric ulcer group): each rat received a single oral dose of aspirin (300 mg/Kg). Group V: each rat received a dose of 0.5ml/Kg of prp subcutaneously two days/week for three weeks then a single oral dose of aspirin. Group VI: each rat received a dose of 500 mg/kg /day of glutamine orally for three weeks and then a single oral dose of aspirin.
Results: No histological difference between gastric mucosa of rats of groups I, II and III. Whereas, numerous changes were noticed in the gastric mucosa of the rats of group IV (aspirin group) while the rats of group V (prp protective group) and of group VI (glutamine protective group) showed nearly a regular structure of their gastric mucosa with better results of prp.
Conclusion: Platelet-rich plasma and glutamine have good protective effects against aspirin-induced acute gastric ulcers in rats but prp is preferable to glutamine.