Introduction: Chemical industry is currently developing new pesticides whose main objective is to overcome the reduction in yields of existing pesticides to which insects are becoming resistant gradually. At the same time, this permanent requirement must consider environmental issues, especially the potential risks for humans and animals. To this end, studies have shown that vitamins due to their antioxidant capacity can reduce the toxic risks of pesticides in vivo.
Aim of the Work: To investigate the possible ameliorative effect of vitamin C and E against hepatotoxicity of lambda cyhalothrin insecticide formulation Ampligo® 150 ZC ( Chlorantraniliprole 9,3% and Lambda cyhalothrin 4,6% ) in rabbit Oryctolagus cuniculus.
Material and Methods: Twenty-four male rabbits were divided into four groups : control (distilled water) , AP (12,24 mg/kg lambda cyhalothrin), CE (200 mg/kg vitamin C+ 20 mg/kg vitamin E), and AP + CE group. Ampligo's effect was evaluated on the weight of the body and liver, food and water intake, biochemical parameters, liver histopathology, and morphometry.
Results: Ampligo reduces body weight gain, and feed intake, decreases liver weight, reduces total bilirubin level (2,14 mg/ L), and increases direct bilirubin serum level. Histopathological study on the liver shows structural disorganization in liver tissue, an increase in the central vein diameter (1209,32 μm) with a thickening of the central vein wall (253,44 μm), and sinusoidal dilatation. Contrarily, the addition of vitamins C and E improved the previous alterations.
Conclusion: Our study indicates that Ampligo 150 ZC causes various disorders in rabbit liver and supplementation with a combination of vitamin C and E reduces the insecticide toxicity.