Introduction: Retina is an organ that is very sensitive to getting hurt because of its high oxygen requirement and high polyunsaturated fatty acid content. Cisplatin is used as an effective chemotherapy in different type of cancer but it reduced the cellular viability and increased the reactive oxygen species (ROS) generation.
Aim of Work: The goal of this work was to investigate the role of nano curcumin particles in preventing the Cisplatin (CP) - induced retinotoxicity in adult male albino rats.
Material and Methods: 30 adult male albino rats divided into three groups as following; group I was the control group, group II was the Cisplatin-treated group (single intraperitoneal injection of CP 7 mg/kg), and group III was the nano curcumin -treated group (single intraperitoneal of CP 7 mg/kg + oral nano curcumin 50 mg/kg/14 d).
Results: Cisplatin (CP) single injection caused histological changes in the retinal tissue and decreased the expression of eNOS level and elevated the caspase-3 as well as the TNF-α in retinal tissue of albino rats. By colorimetric analysis, reduction in the total antioxidant and elevation in MDA levels were also seen. Co-administration of nano curcumin particles with CP restored the normal histological structure of the retina of rats and significantly improved the cellular antioxidant capacity of the retina resulting in retinal protection against the retinotoxicity and apoptotic cell death caused by the CP therapy.
Conclusion: Cisplatin has severe destructive impacts on the retina and co- administration of nano curcumin particles have a protective role on Cisplatin- induced retinotoxicity.