Introduction: Undoubtedly, cancer is distinguished in an incidence of a critical fatality in the world community. There are several models of carcinogenesis by chemical materials utilized in the experimental models. Regarding DMBA, it was validated to be an ideal selective inductor of cancer employed for several purposes in tumor researches.
Aim of the Work: The current consideration was planned to explore the potential alleviating effect of Lagenaria siceraria in conquering detrimental changes induced by 9,10 dimethyl-1, 2-benzanthracene (DMBA) in testes of males Swiss mice.
Materials and Methods: In the existing study, 30 adult male Swiss mice within 90 days of age were evenly distributed into 3 groups as follows; control, DMBA, and DMBA plus Lagenaria siceraria (DMBA + LS). After the experiment timed out which extended for 4 months, the biopsies from testes tissues were dissected and passed the histological, histochemical, and immunohistochemical investigations.
Results: By cross-sectional screening, DMBA is implying a prominent proliferative effect on the spermatocytes and Leydig cells of male mice inferred through dense DNA and RNA synthesis. Furthermore, DMBA rummaged apparent decrement in its protein and polysaccharides. As well, it prompted a lucid infiltration of the collagen fibers around vasculatures. However, Lagenaria siceraria could efficiently suppress stimulatory impact induced by DMBA in epithelial lining seminiferous tubules.
Conclusion: Depending on these findings, it could be concluded that DMBA verily elicited a powerful model of carcinogenesis that progressed by the time distinctly. However, Lagenaria siceraria could potentially ameliorate the deleterious effect disclosed in the testicular cells by carcinogen DMBA.