Salinity is one of the most important environmental stresses affecting agricultural productivity globally. Magnetic field 
and seaweed extract are effective and emerging tools to increase tolerance against adverse environments leading to 
maximizing yields. The current study aimed to clarify the effect of magnetized irrigation water and seaweed extract on growth, yield and the changes in chlorophyll content and mineral composition of squash (Cucurbita pepo L.) cv. El-Eskandarani. This experiment was carried out in the summer 2022 and 2023 seasons at the Experimental Station of Desert Research Center in Ras Sudr, South Sinai Governorate, Egypt. In this experiment, the plants were treated with the magnetic field (untreated water and magnetized water) and different foliar applications of seaweed extract (0, 0.5, 
and 1 g L-1). The results showed that growth parameters, chlorophyll content, NPK content of leaves, yield and its components were increased with irrigation using magnetized water and foliar application of seaweed extract, while the content of Na and Na+/K+ ratio were decreased using magnetized water and foliar application of seaweed extract. The best results in terms of growth, chlorophyll content, mineral content, yield and its components were observed in plants irrigated with magnetized water and sprayed with seaweed extract at 1 g L-1. In conclusion, magnetic treatment of saline water and seaweed extract spraying improved growth and yield of squash plants under saline conditions.