Field experiments were conducted in alkaline soil at the Desert Research Center, Agricultural Experiment Station at El-Kharga Oasis, New Valley Governorate, Southwestern Egypt during the two growing seasons of 2021 and 2022 to study the effect of some tillage systems and some types of organic fertilizers on the maize yield and some alkaline soil properties. Results indicated that all studied parameters were significantly affected by tillage systems and organic fertilizers sources in both seasons. The highest values were obtained when the soil was treated with a disc plough and when adding organic fertilizers in the form of sheep fertilizer, as the grain yield increased by 61.59 and 62.23% in the first and second seasons, respectively.