Although they belong to C4, bicolor sorghum plants are moderately resistant of salt. The growth and development of plants at the seedling stage are adversely affected by high saline levels, such as those found in the study area under consideration (more than 8000 ppm). Additionally, it has an impact on grain output, flower development, fertilization, and the contract process. As a result, the study looks at biochemical indicators stress variables to assess how seven varieties of bicolor sorghum (Roma, Cukorcirok, Ramada, Rex, Shandaweel-1, Shandaweel-15, and MN2756) thrive when exposed to high salinity and how this affects the grains yield, biochemical indicators and nutritional components. The study demonstrated that the Rex variety is distinguished from other sorghum varieties by short stem length, not surpassing 1.5 meters at harvest, medium weight of straw yield, and good grain yield. The outcomes indicated that Rex grain productivity percentage was 32.14% of the plant weight. Rex grains stand out for their high nutritional content, with phenolic compounds at 692.3 µg/g and amino acids at 297.12 mg/g in sorghum flour, respectively. As a result, the Rex variety is thought to be the greatest sorghum variety that was cultivated in Ras Sudr under salt stress conditions.