Climate change could negatively impact black cumin (Nigella sativa) cultivation, changing the crop's characteristics. Thus, the farming of new expanses was necessary. As a result, this research was carried out in Egypt to determine the effect of newly reclaimed regions on production. The study was conducted in four desert locations: El-Hammam, Matrouh Governorate; Oraby Association, Al-Eubour, Qalyubia Governorate; Tour Sinai, South Sinai Governorate; and the western desert hinterland, Minya Governorate. The results revealed that all ecosystems significantly affected growth and yield traits. The highest plant height, fresh and dry weights per plant, capsule numbers per plant, seed yield, and fixed oil per unit area were from the governorates of Minya, followed by South Sinai, Qalyubia, and Matrouh, respectively. The highest content of unsaturated fatty acids and the lowest concentration of saturated fatty acids were from the governorates of Matrouh, followed by Minya, Qalyubia, and South Sinai, in that order. Based on the quantity and quality characteristics, the study recommended cultivating black cumin in newly reclaimed lands in the western desert hinterland of Minya Governorate, then South Sinai Governorate, as new areas for this crop's production.