This article provides information on the morphology, epistemology, and molecular genetics of the cestode species Schyzocotyle acheilognathi (Yamaguti, 1934), which belongs to the genus Schyzocotyle Akhmerov, 1960. This species is a parasite of the digestive systems of the fish Cyprinus carpio Linnaeus, 1758, Carassius gibelio Linnaeus, 1758, and Channa argus Cantor, 1842, in the water reservoirs of the Khorezm region. As a result of this study, samples of S. acheilognathi found in carp and the silver crucian carp were compared. Differences were detected, accounting for 0.36% of the total nucleotide variation. This variation can be attributed to the interaction of environmental factors affecting the host and the environment in which the helminth resides.