Fisheries in the Mediterranean Sea play a critical role in Egypt's economy, yet they face growing challenges from environmental changes, overfishing, and habitat degradation. This study assessed the seasonal and interannual variability of fisheries production in four major Egyptian fishing ports—Port Said, El Arish, Ezbet El Borg, and Borg El Burullus—using 20 years of remote sensing data from the MODIS-Aqua satellite. Key environmental variables, such as sea surface temperature (SST) and chlorophyll-a (Chl-a) concentrations, were analyzed to evaluate their impact on fish production. The results indicate significant spatial and temporal variability in both SST and Chl-a concentrations across the study area, with SST showing an increasing trend over the last two decades, while Chl-a concentrations exhibited a general decline. A negative correlation was observed between SST and Chl-a concentration, suggesting potential shifts in marine productivity. Fisheries data reveal seasonal fluctuations in catch rates, with a decline in total fish production in recent years. This study highlighted the utility of remote sensing as a powerful tool for monitoring and managing fisheries, providing insights that can inform sustainable management practices and policy decisions in the face of climate change and other environmental pressures.