Efforts to develop small and medium industries (IKM) in Indonesia include the implementation of the One Village One Product (OVOP) program, with Karawang Regency being one of the regions where this program is executed. The fish skin processing industry in Tegalsari Village, Cilamaya Wetan Subdistrict, is one of the IKMs in Karawang Regency that has the potential to be developed. However, the industry still needs to face several problems, mainly production and marketing limitations. This research aimed to formulate strategies for developing the fish skin processing industry in the village. The analytical methods employed were supply chain management (SCM) and SWOT analysis. The results of the study produced several strategies needed to develop the fish skin processing industry: (1) supply and marketing networking integration, (2) product development and innovation, (3) strengthening production processes and waste processing, and (4) strengthening human resources.