Marine invertebrate natural products are a potential major source of new drugs for treating diseases, including parasitic infections. Echinodermata is an important invertebrate phylum with approximately 13,000 extinct species known from the fossil record and about 7000 described living species.  In order to develop more effective, targeted, and specific innovative antiparasitic medications, this article reviewed the antiparasitic properties of crude extracts and bioactive chemicals isolated from echinoderms. Articles concerning echinoderm antiparasitic activity published since 1970 have been retrieved, studied, and discussed. Echinoderms appeared to exhibit antitrypanosomal, antileishmanial, antimalarial, antitrichomonal, antigiardial, antischistosomal, and scolicidal activities, and some of the obtained chemicals can be turned into novel antiparasitic drugs in the future.