The northern coastal wetlands suffer from environmental pollution since they receive industrial, domestic, and agricultural drainage wastewater directly without treatments which has a negative impact on water as a substantial natural resource. Thus, this work aimed to assess the suitability of water quality in Manzala and Burullus wetlands for various uses through the determination of some physicochemical parameters. A total number of 32 representative surface water samples were collected and analyzed for pH, EC, salinity, TDS, turbidity, SO₄, Cl^-, HCO₃, Mg⁺, Ca²⁺, K⁺, Na⁺, and some heavy metals, such asPb, Zn, Cu, Fe, and Cd. Two principal models namely water quality and metal indices (WQI, MI) were calculated to briefly estimate the water quality status. The results showed that the values of WQI in the Manzala Wetland ranged from 231.04 to 885.7, while it ranged from 191.8 to 589.8 in the Burullus Wetland. Moreover, the metal index values for irrigation purposes of all, except two stations, were less than 1, and all values for the aquatic life were more than 1. Therefore, nearly all the analyzed water samples from the Manzala and Burullus wetlands can be used for irrigation while categorized as unsuitable for the aquatic life. It is highly recommended that drainage water should be treated before discharging into the wetlands to comply with water quality standards. In addition, temporal assessment of water resources should be constantly conducted to mitigate the potential impacts and sustain water resources.