This study aimed to investigate the growth rate and hematocyte (THC and DHC) profiles in white shrimp (Litopenaeus vannamei) induced by different concentration of artificial seawater and (Caulerpa lentillifera) extract. In this study, white shrimp observing approximately 6-7 cm in length were subjected to various concentrations of different concentration artificial seawater and sea grapes extract. The findings of the study indicated that the treatment of different salinities and water extract of sea grapes shows obvious effect on the growth rate and hemocyte (THC and DHC) in white shrimp. The growth value (SGR and average daily growth) and hemocyte number was significantly increased at the concentration of 10 ppt with 0.65 gram sea grapes extract with around 3.8%, 0.07%, respectively. THC was around 50×10⁴, semi-granul, granul, and hyaline with value 35×10⁴, 30×10⁴ and 70×10⁴, respectively. The concentrations of 10 ppt with 0.65 gram sea grapes extract was also showing the lowest value of ROS below 5 ng/L.