Clams are one of the important varieties of shellfish and perhaps the most versatile seafood in the world.  This study aimed to compare the meat yields and biochemical composition of some commercial bivalves harvested from Lake Timsah. Specimens were purchased from clam collectors working at Lake Timsah in January 2015. The nutritional composition of clams was analyzed at the Regional Center for Food and Agriculture (RCFA) and Agriculture Research Center (ARC), Giza, Egypt.  This study revealed that the highest meat yield was recorded in Ruditapes decussatus compared to other species (Paphia undulata and Venerupis pullastra). The highest protein was recorded in Paphia undulata, while the highest lipid was detected in Venerupis pullastra.