Medicinal plants contain bioactive compounds that boost fish immunity and offer an effective chemical compound alternative. The present experiment aimed to study the effect of Tinospora cordifolia leaf powder on common carp (Cyprinus carpio), evaluating growth performance, hemato-biochemical indices, and serum antioxidant-enzymes activity. The fish species were fed at different levels 0, 2, 4, and 6g/ kg of T. cordifolia leaf powder for 60 days. The results showed that the diet supplemented with 6g/ kg improved significantly (P< 0.05) the growth performance parameters, red blood cell count, hematocrit, hemoglobin, total protein, albumin, and globulin. In addition, the levels of superoxide dismutase, glutathione peroxidase, and lysozyme also rose significantly (P< 0.05). On the other hand, glucose levels decreased significantly (P< 0.05) with T. cordifolia supplementation. This research indicates that T. cordifolia leaf powder is a viable feed additive for improving the growth performance and general health of common carp. Consequently, it would assist in enhancing aquaculture's sustainability.