A total of seventy-two healthy Nile catfish; Clarias gariepinus were distributed into four distinct groups. These groups were fed either a commercial basal diet or a diet enriched with 500 mg curcumin/kg ration for 12 weeks. Among these groups, two groups were exposed to a sublethal concentration of copper (0.35 mg/l) and were fed a normal diet or a curcumin-enriched diet as an antioxidant. The other two control groups were comprised of fish raised in dechlorinated tap water and were fed either the commercial basal diet or the curcumin-supplemented diet for the same 12-week experimental period. The study's findings revealed that Clarias gariepinus, when subjected to a sublethal copper concentration (0.35 mg/l), accumulated a greater amount of copper in their vital organs (gills, liver, and muscles) after 12 weeks. This accumulation coincided with a decrease in fish's rate of growth and quality of meat (indicated by higher muscle water content and ash but lower muscle total protein and lipids), a reduction in RBCs count, Hb content, and Ht values, and an increase in WBCs count, serum glucose, creatinine, uric acid, total protein, albumin, globulin levels, A/G ratio, and AST, ALT and ALP activities when compared to the control group of fish with a highly significant difference (P < 0.01). However, fish that were exposed to copper toxicity and fed curcumin supplemented diet (500 mg/kg diet) exhibited values that were more or less similar to those of the control group of fish that were reared in dechlorinated tap water and fed a commercial basal diet or curcumin supplemented basal diet (500mg/kg diet).