Carcinogenic and other health risks associated with consuming fish have been evaluated using the selected six fish species including Dicentrarchus labrax, Clarias gariepinus, Sarotherodon galilaeus, Oreochromis aureus, Oreochromis niloticus and Tilapia zillii from Idku Lake, Egypt. To estimate the non-carcinogenic (estimated daily intake (EDI), target hazard quotient (THQ) and carcinogenic human health risks (CR), the concentrations of heavy metals (Fe, Cr, Ni, Pb and Cd) in the liver and muscles tissue of six fish species were addressed. The estimated daily intake (EDI) showed that the highest concentration was in iron but this value was the only value in the heavy metal concentrations that didn't exceed the permissible limit. The total values of this indicator (tTHQ) were determined for fish species, and a noticeable increase was recorded in the values for the lead element. However, the values range are less than 1.00, indicating no discernible health. Clarias gariepinus had values ​​of 1 that can affect human health in the long term. While for carcinogenic human health risks (CR), the highest value was recorded in the liver of clarias gariepinus fish, and it exceeds the recommended ratios. All the remaining values of heavy metals were within the recommended ranges, which indicates that there is no tangiblehealth risk to humans.