The effect of the immersion or soaking of different extracts of Caulerpa lentillifera in profile hematology and phagocytosis as immune responses is still unknown. In this research, the effect of three extractions of Caulerpa lentillifera (extracts of ethanol, methanol and water) was determined on the profile hematology and phagocytosis activity. Briefly, 8- 10cm carp (Cyprinus carpio) were exposed to each extract with different concentrations (0; 0.24, 0.32, 0.42, 0.65 and 0.87ppm) by immersion or soaking for 96 hours.  The result showed that the ethanol extract of Caulerpa lentillifera increased immune response. The ethanol extract showed significant increases in erythrocyte, leukocyte and phagocytosis activity at a concentration of 0,42 ppm around 1.43.10⁶ cells/ mm³, 30.10³ cells/ mm³ and 35%, respectively.  However,  methanol and water extracts showed increasing immune responses with no significance compared to ethanol extract. Furthermore, ethanol extract showed different responses in fish morphology. It was induced by enhancing the appearance of the fish's color, as well as swimming more actively than a sample treated with methanol and water extracts.