This study aimed to assess the impact of chemically treated litter on the growth performance, carcass traits, health status and economic efficiency of broilers. A total of 180 one-day-old Ross broiler chicks were distributed into six groups, each consisting of three replicates with 10 chicks per replicate. The control group (C) was raised on untreated wheat straw litter, while the other groups (T1, T2, T3, T4, and T5) were provided with litter amended with 10% sand, clay, zeolite, litter guard and biochar, respectively. Results regarding growth performance metrics such as body weight, gains, feed consumption and feed conversion ratio indicated significant differences (P≤0.05) among the various litter treatments at different stages. Broilers raised on litter treated with 10% biochar and 10% litter guard demonstrated notably higher body weights and improved feed conversion compared to those raised on untreated or chemically treated litters. No significant differences were observed in giblets, but birds raised on litter amended with 10% biochar exhibited the highest dressed carcass. Additionally, lower abdominal fat percentages were noted in broilers raised on litter treated with 10% sand, biochar and litter guard. Furthermore, birds raised on litter treated with 10% sand, biochar and litter guard showed significantly lower bursa percentages and fewer leg problems compared to those raised on other litter treatments. Considering cost-effectiveness and availability, certain chemical treatments may serve as beneficial supplements to conventional litter. In conclusion, chemically treated litter incorporating 10% sand, biochar and litter guard holds promise as effective litter amendments for managing broilers.