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354612

Dietary Intervention using Reishi Mushroom (Ganoderma Lucidum) Reduces Oxidative Stress and Enhances Erythrocyte/Serum Defense Systems in Alloxan-Induced Diabetic Rats

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Food Science and technology

Abstract

Diabetes mellitus (DM) is a metabolic disease that causes high blood glucose which is called hyperglycemia. In addition to hyperglycemia, oxidative stress, which raises the risk of complications, is one of the many other important factors that contribute significantly to the pathogenesis of diabetes. The goal of the current study was to determine how well (Ganoderma lucidum) ethanol extract (GLE) intervenes against oxidative stress in living cells, with a focus on its mechanistic elements in the management of diabetes mellitus. Rats treated with alloxan showed a significant (p≤0.01) increase in serum glucose levels from 92.67 mg/dL in normal control rats to 311.24 mg/dL in treated rats. Serum glucose levels in rats fed GLE (200, 400, 600, and 800 mg/kg bw) for 28 days showed a significant (p≤0.05) decline, with values recorded at 294.26, 268.34, 210.17, and 192.78, respectively. With GLE intervention, there was a dose-dependent increase in the rate of serum glucose decrease. The biochemical indicators of oxidative stress levels in plasma, nitric oxide (NO), malonaldehyde (MDA), and reactive oxygen species (ROS), all exhibited the same conduct. However, there was a notable (P≤0.05) increase in the various antioxidant protective mechanisms in the serum, which included bioactive molecules (GSH fractions), antioxidant vitamins (A, C, and E), and antioxidant enzymes [glutathione peroxidase (GSH-Px), glutathione reductase (GSH-Rd) superoxide dismutase (SOD) and catalases (CAT)]. Ultimately, these results establish a foundation for the application of (Ganoderma lucidum) extracts in the prevention and/or treatment of T2D by inhibiting oxidative stress, which is one of the factors contributing to the illness and its consequent challenges.

DOI

10.21608/asejaiqjsae.2024.354612

Keywords

hyperglycemia, glutathione, Antioxidant enzymes, antioxidant vitamins, Reactive oxygen species, malonaldehyde, Nitric oxide

Authors

First Name

Yousif Abd Elasis

Last Name

Elhassaneen

MiddleName

-

Affiliation

Department of Nutrition and Food Science, Faculty of Home Economics, Minoufiya University, Shebin El-Kom, Egypt

Email

yousif12@hotmail.com

City

Shebin El-Kom,

Orcid

0000-0003-1391-3653

First Name

Sarah

Last Name

S. Aggad

MiddleName

-

Affiliation

Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, Saudi Arabia

Email

sara.aggad@kau.edu.sa

City

-

Orcid

-

First Name

Eman Badwy

Last Name

Mehram

MiddleName

-

Affiliation

Home Economics Department, Faculty of Specific Education, Benha University, Benha;

Email

eman.moharam@fsed.bu.edu.eg

City

Benha

Orcid

-

Volume

45

Article Issue

2

Related Issue

47194

Issue Date

2024-06-01

Receive Date

2024-04-10

Publish Date

2024-06-30

Page Start

219

Page End

237

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 45_Issue 2_Pages 219-237.pdf

PDF . 705.5kB

Link

https://asejaiqjsae.journals.ekb.eg/article_354612.html

Detail API

https://asejaiqjsae.journals.ekb.eg/service?article_code=354612

Order

1

Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

Dietary Intervention using Reishi Mushroom (Ganoderma Lucidum) Reduces Oxidative Stress and Enhances Erythrocyte/Serum Defense Systems in Alloxan-Induced Diabetic Rats

Details

Type

Article

Created At

23 Dec 2024