It became necessary to employ safer and more efficient alternatives to plant pathogenic bacteria and land snails control due to the growing issues these snails and bacteria were causing on various crops. Green nanoparticles have been used because of their stability, low-cost feasibility and antimicrobial characteristics and snails. The current work intends to investigate the effectiveness of green synthetic silver and iron oxide nanoparticles of an aqueous extract of Acacia nilotica pods Ag-NPs (AEANP-AgNPs) and FeO-NPs (AEANP-FeONPs) against two identified plant pathogenic bacterial strains (Xanthomonas euvesicatoria and Pseudomonas syringae pv. tomato) and to land snails (Monacha cartusiana and Eobania vermiculata) collected from sandy loam soil. AEANP-AgNPs and AEANP-FeONPs were made and characterized using a TEM, Zeta potential, FTIR and EDX. Different concentrations of AEANP-AgNPs (1700, 3400, and 5100 ppm) and AEANP-FeONPs (2700, 5400, and 8100 ppm) were tested. The concentration (5100 ppm) of Ag-NPs was higher in the inhibition against P. syringae pv. tomato while (5400 ppm) and (8100 ppm) concentrations of FeO-NPs were equal to inhibition against X. euvesicatoria. In planta, the treated strain of X. euvesicatoria exhibited low severity while the treated strain of P. syringae pv. tomato didn't exhibit a significant difference severity. So, M. cartusiana snails were more sensitive to the toxic effect of Ag-NPs and FeO-NPs than adult snails, E. vermiculata. The mortality for adult snails was increased with increasing concentration of both nanoparticles. The LC50 concentrations of Ag-NPs for adult snails M. cartusiana and E. vermiculata were (1.885×103and 7.618×103) and (4.066×103 ppm and 10.776×103 ppm) for FeO-NPs respectively.