During the 2018 and 2019 seasons, field trials were conducted at Farmer's Field in EL-Borulls district, Kafr Elsheikh Governorate, Egypt. to investigate and evaluate the impact of three irrigation regimes—irrigating tomato plants at 100% (I1), 85% (I2), and 70% (I3) of ETc—as well as three organo-mineral fertilization treatments—F1 (100% RNPK + 33% of recommended poultry manure (R.P.M.)), F2 (75% RNPK + 50% of R.P.M.), and F3 (50% RNPK + 60% of R.P.M) – on tomato fruit yields, quality, some water relations and economic return. Results revealed that both I2 and F2 treatments in both seasons produced the most fruit of tomato and its components. When comparing the two seasons as a whole, irrigation with (I2) increased fruit output by (4.12%) compared to irrigation with (I1), while the comparable value with (F2) increased fruit yield by (10.21%) compared to that with (F1). The combination of (I3F3) produced the highest levels of TSS, %, vitamin C, and acidity, % during both seasons. Furthermore, maximum productivity of irrigation water and water savings, % were discovered with (I3) during both seasons. The combination of (I2F2) produced the highest levels of economic efficiency and net return, whereas the combination of (I3F2) in the two seasons, achieved the highest net return from a water unit. It is possible to conclude that the most effective method for increasing the economic fruit output and quality of tomatoes while conserving both water and mineral fertilizers is the combination of (I2F2) or (I2F3).