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387919

Pre-emptive epinephrine nebulization prior to nasotracheal intubation for mandibular fracture fixation surgeries: Does it really differ? A randomised controlled clinical trial

Article

Last updated: 05 Jan 2025

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Abstract

Introduction
Isolated mandibular fractures as any other fracture are associated with pain and inflammation which possess difficulty for both laryngoscopy and intubation. Nasotracheal intubation is relatively more efficient in individuals with isolated mandibular injuries. Epistaxis is the most common complication of nasal intubation. This study aimed to highlight the role of preoperative usage of epinephrine 1:1000 combined with lidocaine as a nebulization session before induction of anaesthesia as a method to spread vasoconstriction and analgesia.
Methods
The patients were randomly assigned to one of two equal groups; nasal Lidocaine drops followed by Oxymetazoline nasal drops (OL as control group) or Epinephrine mixed with Lidocaine as nebulization session (EL as the study group). Our primary measures were to estimate the degree of epistaxis and its effect on intubation time.
Results
Lidocaine with epinephrine as a nebulization session prior to NTI has statistically significant less intubation time (37.8 ± 6.32) versus (42.16 ± 5.1) in the control group with - value (0.000028). This correlates with higher incidence of moderate nasal bleeding in OL group (7/60 = 11.66%) versus (4/60 = 6.66%) in EL group and - value = 0.01. EL mixture has a higher priority of decreasing surgical blood loss. Mean± SD measures were (406.86 ± 89.6) and (468.6 ± 139), p-value = 0.00026*in EL and OL groups respectively.
Conclusion
Despite being time consuming measure. Yet, lidocaine epinephrine nebulization session can be considered as an efficient method for prophylaxis against nasotracheal intubation induced epistaxis, to control intraoperative field bleeding, acts as an adjuvant to control intraoperative pain and protects against postextubation nasal complications.

DOI

TEJA-2023-0046

Keywords

Nasotracheal intubation, oxymetazoline drops, nebulized epinephrine, Mandibular fracture, epistaxis

Authors

First Name

Rehab Abdelfattah

Last Name

Abdelraziq

MiddleName

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Affiliation

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Email

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Orcid

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First Name

Sabah Nagiub Barsoom

Last Name

Ayoub

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Hagar Mahmoud

Last Name

El-Sherief

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Mohammed Sayed

Last Name

Shorbagy

MiddleName

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Affiliation

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Email

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City

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Orcid

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Volume

39

Article Issue

1

Related Issue

51163

Issue Date

2023-12-01

Receive Date

2023-02-24

Publish Date

2023-12-31

Page Start

348

Page End

355

Print ISSN

1110-1849

Online ISSN

1687-1804

Link

https://egja.journals.ekb.eg/article_387919.html

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https://egja.journals.ekb.eg/service?article_code=387919

Order

387,919

Publication Type

Journal

Publication Title

Egyptian Journal of Anaesthesia

Publication Link

https://egja.journals.ekb.eg/

MainTitle

Pre-emptive epinephrine nebulization prior to nasotracheal intubation for mandibular fracture fixation surgeries: Does it really differ? A randomised controlled clinical trial

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Type

Article

Created At

21 Dec 2024