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387752

Case report: successful prophylactic use of intravenous lipid emulsion to prevent local anesthetic systemic toxicity after inadvert intravenous administration of bupivacaine

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Last updated: 21 Dec 2024

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Abstract

Bupivacaine is a local anesthetic drug that carries catastrophic adverse effects. On exceeding the toxic dose significant cardiotoxic and neurotoxic consequences emerge. The maximal toxic dose of Bupivacaine for local applications is 2 mg.kg-1. The exact hazardous dose for intravenous administration is unknown. Abdominal hysterectomy was scheduled for our 57-year-old patient. She received 20 mg of Bupivacaine intravenously by accident and showed no evidence of cardiac or neurological toxicity. The explanation for this is unknown, although it could be owing to the very low dose, which was less than the toxic amount, or to our patient’s early lipid emulsion prophylaxis.

DOI

TEJA-2021-0087

Keywords

Local anesthetic toxicity, Bupivacaine, lipid emulsion, Hysterectomy

Authors

First Name

Reham

Last Name

Mahrous

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First Name

Ahmed

Last Name

Kareem

MiddleName

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First Name

Ayman M.

Last Name

Hussam

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First Name

Omnia A.

Last Name

Mandour

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Volume

37

Article Issue

1

Related Issue

51159

Issue Date

2021-01-01

Receive Date

2021-06-14

Publish Date

2021-01-01

Page Start

326

Page End

328

Print ISSN

1110-1849

Online ISSN

1687-1804

Link

https://egja.journals.ekb.eg/article_387752.html

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https://egja.journals.ekb.eg/service?article_code=387752

Order

387,752

Publication Type

Journal

Publication Title

Egyptian Journal of Anaesthesia

Publication Link

https://egja.journals.ekb.eg/

MainTitle

Case report: successful prophylactic use of intravenous lipid emulsion to prevent local anesthetic systemic toxicity after inadvert intravenous administration of bupivacaine

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Article

Created At

21 Dec 2024