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383722

Parameter-dependent transmission dynamics and optimal control of foot and mouth disease in a contaminated environment

Article

Last updated: 29 Dec 2024

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Abstract

bstract
The problem of foot and mouth disease (FMD) is of serious concern to the livestock
sector in most nations, especially in developing countries. This paper presents the
formulation and analysis of a deterministic model for the transmission dynamics of
FMD through a contaminated environment. It is shown that the key parameters that
drive the transmission of FMD in a contaminated environment are the shedding,
transmission, and decay rates of the virus. Using numerical results, it is depicted that
the host-to-host route is more severe than the environmental-to-host route. The model
is then transformed into an optimal control problem. Using the Pontryagin's Maximum
Principle, the optimality system is determined. Utilizing a gradient type algorithm with
projection, the optimality system is solved for three control strategies: optimal use of
vaccination, environmental decontamination, and a combination of vaccination and
environmental decontamination. Results show that a combination of vaccination and
environmental decontamination is the most optimal strategy. These results indicate
that if vaccination and environmental decontamination are used optimally during an
outbreak, then FMD transmission can be controlled. Future studies focusing on the
control measures for the transmission of FMD in a contaminated environment should
aim at reducing the transmission and the shedding rates, while increasing the decay rate.

DOI

10.1186/s42787-019-0058-1

Keywords

Parameter dependent, FMD, Contaminated environment, optimal control

Authors

First Name

Francis

Last Name

Mugabi

MiddleName

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Affiliation

College of Natural Sciences, Makerere University, Wandegeya, P. O. Box 7062 Kampala, Uganda

Email

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City

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Orcid

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First Name

Joseph

Last Name

Mugisha

MiddleName

-

Affiliation

College of Natural Sciences, Makerere University, Wandegeya, P. O. Box 7062 Kampala, Uganda

Email

-

City

-

Orcid

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First Name

Betty

Last Name

Nannyonga

MiddleName

-

Affiliation

College of Natural Sciences, Makerere University, Wandegeya, P. O. Box 7062 Kampala, Uganda

Email

-

City

-

Orcid

-

First Name

Henry

Last Name

Kasumba

MiddleName

-

Affiliation

College of Natural Sciences, Makerere University, Wandegeya, P. O. Box 7062 Kampala, Uganda

Email

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City

-

Orcid

-

First Name

Margaret

Last Name

Tusiime

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

-

Volume

27

Article Issue

1

Related Issue

50652

Issue Date

2019-12-01

Receive Date

2024-10-03

Publish Date

2019-12-01

Page Start

1

Page End

21

Print ISSN

1110-256X

Online ISSN

2090-9128

Link

https://joems.journals.ekb.eg/article_383722.html

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https://joems.journals.ekb.eg/service?article_code=383722

Order

383,722

Publication Type

Journal

Publication Title

Journal of the Egyptian Mathematical Society

Publication Link

https://joems.journals.ekb.eg/

MainTitle

Parameter-dependent transmission dynamics and optimal control of foot and mouth disease in a contaminated environment

Details

Type

Article

Created At

21 Dec 2024