In this paper, we propose a novel algorithm to detect the suspicious regions on digital
mammograms that based on the Fisher information measure. The proposed algorithm is tested different
types and categories of mammograms (fatty, fatty-glandular and dense glandular) within
mini-MIAS database (Mammogram Image Analysis Society database (UK)). The proposed method
is compared with a different segmentation based information theoretical methods to demonstrate
their effectiveness. The experimental results on mammography images showed the effectiveness in
the detection of suspicious regions. This study can be a part of developing a computer-aided decision
(CAD) system for early detection of breast cancer.