Annona squamosa a member of the Annonaceae family is an important fruit cultivated in Egypt, Bermuda, Brazil, India, Mexico, South and Central America, considered a notable source of secondary metabolites with a broad range of biological activities including antimicrobial, antiprotozoal, anticancer, antidiabetic and antioxidant activity. The sugar apple fruit is prized for both its full nutritional profile and edible flavor. It is a great source of several vital nutrients, such as antioxidants, potassium, magnesium, iron, vitamins (including C, B6, and riboflavin), and dietary fibers. This study aims to incorporate existing data on A. squamosa's phytochemicals, traditional applications, and bioactivities based on several studies, with the ultimate goal of advancing knowledge of the plant's potential medical benefits.