Senna is a Fabaceae family with approximately 250-300 approved species dispersed throughout tropical and subtropical areas. Senna spp. have a common use in Africa, Asia, Europe, and Latin America for their laxative, anti-bacterial and anti-inflammatory activities, which have been used in folk medicine to cure diabetes, microbiological diseases, and malaria. This review was developed by doing a thorough search of present publications. Most important active constituents in the genus include anthraquinones, steroids, alkaloids, tannins, flavonoids, glycosides, terpenoids, saponins, and essential oils. Senna extracts and metabolites exhibit a variety of pharmacological activities, including anti-diabetic, anti-microbial, antioxidant, wound healing, anti-lipogenic and anti-inflammatory activities. This review surveys some recent breakthroughs in phytochemical and pharmacological research investigations of Senna, offering a valuable resource for future research and medical uses. Senna species have long been applied for therapeutic intents, with potent traditional evidence supporting their activities. Further research should focus on identifying active constituents responsible for pharmacological actions, structural elucidation, and toxicological activities.