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360813

Diagnostic Utility of Aquaporin-4 blood level in Neonatal Hypoxic Ischemic Encephalopathy

Article

Last updated: 29 Dec 2024

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Clinical Biochemistry

Abstract

 Background: hypoxic-ischemic encephalopathy is one of the most important diseases in neonates.
Objective: to evaluate the use of the blood level of aquaporin-4 in the diagnosis of hypoxic ischemic encephalopathy in neonates, and to determine the severity of hypoxia.
Patients and Methods: a case-control study, was carried out on 40 hypoxic neonates, sample (1) at the age of 2 days while sample (2) at the age of (7) days, and 40 samples from a healthy control. The collected blood samples were used to measure the aquaporin-4 level. A clinical neurological examination was done to detect patients with HIE.
Results: there was a statistically significant higher increase of AQP4 in cases than controls and a significant increase of it from the 2nd day to the 7th day, all cases had delayed crying after birth and most of them were hypotonic and most of them had convulsions, most of the cases had convulsions highly significant correlation between Aquaporin 4 level and the severity of ischemic hypoxic encephalopathy in neonates either at 2 or 7 days of age.
Conclusion: it is found that hypoxia leads to an increase in serum Aquaporin-4 level, serum Aquaporin-4 level could be used as an early predictor in the diagnosis of hypoxic-ischemic encephalopathy, and serum Aquaporin-4 level in differentiation between grades of hypoxia gives us better sensitivity and specificity. 

DOI

10.21608/ijabmb.2024.360813

Keywords

aquaporin-4, hypoxia, Neonates, Encephalopathy, ischemia

Authors

First Name

Dalia Saber

Last Name

Morgan

MiddleName

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Affiliation

Pediatrics department, Faculty of Medicine, Beni-Suef University, Beni-Suef 62511, Egypt.

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Orcid

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First Name

Hend Abdel Aziz Taha

Last Name

Masoud

MiddleName

-

Affiliation

Pediatrics department, Beni-Suef general hospital, Beni-Suef University, Beni-Suef 62511, Egypt.

Email

-

City

-

Orcid

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First Name

Shaimaa Ali

Last Name

Abdelkareem

MiddleName

-

Affiliation

Clinical and chemical pathology department, Faculty of Medicine, Beni-Suef University, Beni-Suef 62511, Egypt.

Email

-

City

-

Orcid

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First Name

Mohamed Adel

Last Name

Abdel Tawab

MiddleName

-

Affiliation

Pediatrics department, Faculty of Medicine, Beni-Suef University, Beni-Suef 62511, Egypt.

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City

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Orcid

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Volume

1

Article Issue

2

Related Issue

48442

Issue Date

2024-06-01

Receive Date

2024-06-14

Publish Date

2024-06-01

Page Start

26

Page End

50

Print ISSN

3009-7630

Online ISSN

3009-7991

Article File

IJABMB_Volume 1_Issue 2_Pages 26-50.pdf

PDF . 361.2kB

Link

https://ijabmb.journals.ekb.eg/article_360813.html

Detail API

https://ijabmb.journals.ekb.eg/service?article_code=360813

Order

360,813

Type

Original Article

Type Code

3,170

Publication Type

Journal

Publication Title

International Journal of Applied Biochemistry and Molecular Biology

Publication Link

https://ijabmb.journals.ekb.eg/

MainTitle

Diagnostic Utility of Aquaporin-4 blood level in Neonatal Hypoxic Ischemic Encephalopathy

Details

Type

Article

Created At

21 Dec 2024