Beta
ManageSearchChatDiscover
359919

Comparative study between misoprostol alone versus misoprostol with isosorbide mononitrate in case of second trimester termination of pregnancy in patients with previous caesarea

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Clinical Biochemistry
Clinical Toxicology

Abstract

 Background: Misoprostol is a medication that is frequently used to end second-trimester abortions. Isosorbide mononitrate (ISMN), a nitric oxide donor, has been used to induce labor and ripen the cervix.
Objective: Our goal was to assess the effects of misoprostol alone vs misoprostol with ISMN on cervical ripening and abortion induction during the second trimester of pregnancy.
Patients and Methods: This was a randomized clinical trial performed on 100-second trimesters missed abortion pregnant females. Patients were randomly allocated to either group A (n=50) received combined ISMN 40 mg with Misoprostol 100 mcg or group B (n=50) received only vaginal Misoprostol 100 mcg. Ultrasound was performed to identify the gestational age, ensure that there was no cardiac pulsation of the fetus, the site of the placenta, and if there was placental hematoma or separation, any fetal anomalies, and the state of the previous scar (intact scar).
Results: The 2nd-trimester termination of pregnancy using ISMN plus misoprostol takes a significantly shorter time than misoprostol alone. In the misoprostol group, 6 women (12%) was significantly less than the ISMN + Misoprostol group where 15 (30.0%) aborted after the first dose. There was a non-significant difference after 2nd dose, further 18/44 (40.9%) women aborted in the misoprostol group and 16/35 (45.7%) women in ISMN with the misoprostol group.
Conclusion: The use of ISMN in addition to misoprostol in medical induction of second-trimester abortion may be more effective than misoprostol alone and was associated with fewer side effects such as vomiting and colic except headache was more with isosorbide mononitrate. 

DOI

10.21608/ijabmb.2024.359919

Keywords

misoprostol, Isosorbide mononitrate, Abortion, Second Trimester

Authors

First Name

Sherwet M.

Last Name

Shawkey

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Beni-Suef University, Beni-Suif, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohamed A M

Last Name

Eweis

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Beni-Suef University, Beni-Suif, Egypt.

Email

-

City

-

Orcid

-

First Name

Mai

Last Name

Shabaan

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Fayoum Hospital, Fayoum, Egypt

Email

-

City

-

Orcid

-

First Name

Amira

Last Name

Elgamel

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Beni-Suef University, Beni-Suif, Egypt.

Email

-

City

-

Orcid

-

Volume

1

Article Issue

1

Related Issue

48441

Issue Date

2024-01-01

Receive Date

2024-06-10

Publish Date

2024-01-01

Page Start

42

Page End

60

Print ISSN

3009-7630

Online ISSN

3009-7991

Article File

IJABMB_Volume 1_Issue 1_Pages 42-60.pdf

PDF . 329.3kB

Link

https://ijabmb.journals.ekb.eg/article_359919.html

Detail API

https://ijabmb.journals.ekb.eg/service?article_code=359919

Order

359,919

Type

Original Article

Type Code

3,170

Publication Type

Journal

Publication Title

International Journal of Applied Biochemistry and Molecular Biology

Publication Link

https://ijabmb.journals.ekb.eg/

MainTitle

Comparative study between misoprostol alone versus misoprostol with isosorbide mononitrate in case of second trimester termination of pregnancy in patients with previous caesarea

Details

Type

Article

Created At

21 Dec 2024